MOTS-c
Mitochondrial Open Reading Frame of the 12S rRNA-c (16-AA Peptide)
Pre-Clinical Overview
MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA locus. Investigated in metabolic biology laboratories for its regulation of the folate-methionine cycle, direct activation of AMPK, and restoration of metabolic plasticity.
Verified UK Suppliers for MOTS-c
| Supplier | Assay Purity | Reagent Format | Dispatch Location | Notes | Access |
|---|---|---|---|---|---|
| PharmaGrade Store | ≥99.0% (HPLC) | vial | United Kingdom (Royal Mail 24) | High-purity lyophilized 10mg reagent vials with verified mitochondrial peptide sequence. | |
| Direct Peptides | ≥98.9% (HPLC) | vial | UK Hub & Europe | Research grade lyophilized peptide vials with automated mass spectrometry confirmation. | |
| Direct Sarms | ≥98.5% (HPLC) | vial | United Kingdom Express | Analytical reference standard vials tested for AMPK activation assays. | |
| Peptide Works | ≥98.7% (HPLC) | vial | Manchester UK Hub | Northern UK laboratory dispatched lyophilized reagent vials with sequence COA. | |
| PharmaLab Global | ≥99.2% (HPLC) | vial | London UK Hub | Triple-stage assayed vials and pre-calibrated laboratory multi-dose pen formats. |
Molecular Signaling Pathways
- 1Translocates to the nucleus under metabolic stress to regulate nuclear gene expression via antioxidant response elements (ARE).
- 2Directly activates adenosine monophosphate-activated protein kinase (AMPK) through inhibition of the folate cycle.
- 3Enhances cellular glucose uptake in myotubes via GLUT4 translocation independent of classical insulin signaling.
- 4Prevents high-fat diet-induced insulin resistance and mitigates cellular oxidative stress in mitochondrial assays.
Laboratory Evaluation Guidelines
Hydrophobic and thermally sensitive peptide requiring precise cold-chain handling during reconstitution to avoid aggregation and precipitation.
Receptor Affinity, SPPS Synthesis & Pharmacokinetics
Standardized chemical parameters, solid-phase synthesis criteria, and quantitative receptor affinity benchmarks for MOTS-c.
- AMPK phosphorylation at Thr172
- Inhibition of the folate-methionine cellular cycle
- Glucose uptake stimulation via GLUT4 translocation
Documented Biochemical Endpoints & Statistical Significance
| Study Design | Cohort (n) | Measured Biological Endpoint | Statistical Significance | NCBI Citation |
|---|---|---|---|---|
| In Vitro Assay | n = 28 skeletal myocyte cultures | AMPK phosphorylation and folate cycle metabolite levels | p < 0.001 vs baseline | PMID 25738459 |
| Preclinical In Vivo | n = 36 contractile endurance models | Treadmill running capacity and skeletal muscle insulin sensitivity | p < 0.01 | PMID 33479210 |
Indexed Scientific Literature
Curated Scientific Q&A for MOTS-c
Authoritative pre-clinical, analytical, and statutory handling guidelines for laboratory researchers.
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c (16-AA Peptide)) is indexed in the CAS Registry under #1627580-64-6. Its empirical molecular formula is C101H152N28O22S2 with a monoisotopic molecular weight of 2174.62 g/mol. It is cataloged under the Cellular Longevity & Mitochondrial Axis research classification.
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