Biological Pathway Hub

Cellular Longevity & Mitochondrial Axis

Telomeric Chromatin Architecture & Mitochondrial-Derived Bioenergetics

Investigative profiles of synthetic tetrapeptides and mitochondrial open reading frame-derived peptides analyzed for telomerase catalytic subunit (hTERT) activation, cardiolipin preservation, and cellular ROS mitigation.

Signaling Focus: TERT gene promoter activation, AMPK phosphorylation, complex I/IV electron chain stabilization, cellular stress resistance.

2 Compound Monographs Indexed

Reagents in this Signaling Category

Mixed Pre-ClinicalCAS 307297-39-8

Epithalon

Synthetic Pineal Tetrapeptide (Ala-Glu-Asp-Gly)

C14H22N4O9390.35 g/molCellular Longevity & Mitochondrial Axis

Epithalon (Epitalon) is a synthetic tetrapeptide modeled on the endogenous pineal extract epithalamin. Studied extensively in biogerontology laboratories for its ability to overcome the Hayflick limit via telomerase catalytic subunit (hTERT) transcription and chromatin remodeling.

Verified UK Sourcing Partners:

PharmaGrade Store (≥99.4% (HPLC))Direct Peptides (≥99.2% (HPLC))Direct Sarms (≥98.8% (HPLC))Peptide Works (≥99.1% (HPLC))PharmaLab Global (≥99.5% (HPLC))

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Mixed Pre-ClinicalCAS 1627580-64-6

MOTS-c

Mitochondrial Open Reading Frame of the 12S rRNA-c (16-AA Peptide)

C101H152N28O22S22174.62 g/molCellular Longevity & Mitochondrial Axis

MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA locus. Investigated in metabolic biology laboratories for its regulation of the folate-methionine cycle, direct activation of AMPK, and restoration of metabolic plasticity.

Verified UK Sourcing Partners:

PharmaGrade Store (≥99.0% (HPLC))Direct Peptides (≥98.9% (HPLC))Direct Sarms (≥98.5% (HPLC))Peptide Works (≥98.7% (HPLC))PharmaLab Global (≥99.2% (HPLC))

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